AA-CYP-HETE/EETs代谢通路与心血管疾病治疗药物研究现状的分析
Analysis of the research status of AA-CYP-HETE/EETs metabolic pathways and cardiovascular disease therapeutic drugs
胡明霞 1何永芸 1姚玥 1莫晓丹 1杨秀芬1
作者信息
- 1. 广西中医药大学药学院,广西壮族自治区 南宁 530200;广西中医药大学广西壮瑶药重点实验室,广西壮族自治区 南宁 530200;广西中医药大学广西高校中药神经-代谢及免疫药理重点实验室,广西壮族自治区 南宁 530200
- 折叠
摘要
20-羟基二十碳四烯酸(20-HETE)及环氧二十碳三烯酸(EETs)是花生四烯酸(AA)经细胞色素P450(CYP)酶系代谢的产物.20-HETE主要由CYP4A、CYP4F将AA代谢产生,对心脑血管系统有一定的毒性作用.EETs主要由CYP2J、CYP2C将AA代谢产生,对心脑血管系统有一定的保护作用.本文通过查阅文献综述AA-CYP-HETE/EETs代谢通路相关药物对心肌肥厚、高血压、心力衰竭、心肌梗死等心血管疾病的作用及作用机制,以期为心血管疾病的临床用药提供参考,为心血管疾病治疗药物的研究和开发提供思路与方向.
Abstract
20-hydroxyeicosatetraenoic acid(20-HETE)and epoxyeicosatrienoic acids(EETs)are products of enzyme metabolism of arachidonic acid(AA)by cytochrome P450(CYP).20-HETE is mainly produced by CYP4A,CYP4F metabolism of AA,which has a certain toxic effect on the cardiovascular and cerebrovascular system.EETS is mainly produced by CYP2J,CYP2C metabolizes AA,which has a certain protective effect on the cardiovascular and cerebrovascular system.This article reviews the effects and mechanisms of drugs related to AA-CYP-HETE/EETs metabolic pathway on cardiovascular diseases such as myocardial hypertrophy,hypertension,heart failure,and myocardial infarction,in order to provide a reference for the clinical use of cardiovascular diseases and provide ideas and directions for the basic research and development of cardiovascular disease treatment drugs.
关键词
花生四烯酸/细胞色素P450/20-羟基二十碳四烯酸/环氧二十碳三烯酸/心血管疾病Key words
arachidonic acid/cytochrome P450/20-hydroxyeicosatetraenoic acid/epoxyeicosatrienoic acid/cardiovascular disease引用本文复制引用
基金项目
广西自然科学基金资助项目(2015GXNSFDA139023)
广西自然科学基金资助项目(2020GXNSFAA297165)
广西壮瑶药重点实验室建设项目计划基金资助项目(GXZYZZ2020-08)
广西壮瑶药重点实验室建设项目计划基金资助项目(GXZYZZ2022-08)
广西中医药大学广西一流学科(中药学)建设开放课题基金资助项目(2019XK122)
出版年
2024
国家科技期刊平台
NSTL
万方数据