首页|基于NLRP3炎症小体探讨中药抗炎作用的研究现状

基于NLRP3炎症小体探讨中药抗炎作用的研究现状

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
炎症小体是一种细胞内多蛋白复合体,是人体组织受损后构成局部炎性微环境复杂体系的重要成分.当炎症小体被激活后诱导胱天蛋白酶-1(caspase-1)的活化,介导促炎细胞因子的成熟及分泌,如白细胞介素(IL)-1β和IL-18,并诱导细胞的焦亡,在调节宿主对病原体感染的免疫应答和细胞损伤的组织修复中发挥着重要作用.由NOD样受体蛋白3(NLRP3)、胱天蛋白酶-1前体(pro-caspase-1)和衔接蛋白凋亡相关斑点样蛋白(ASC)组成的NLRP3炎症体是目前研究的最为深入和广泛的炎症小体类型,在炎症调节过程中起着至关重要的作用.当NLRP3炎症小体被激活后,产生和释放炎症介质,参与多种炎症疾病的发生与发展.中医药能够通过抑制NLRP3炎症小体,改善多种疾病的病理状态,发挥防治多种炎症疾病的作用,包括心血管系统疾病、关节炎症、糖尿病等.本文系统性地梳理了 NLRP3炎症小体在多种炎症疾病中的作用机制,并总结了中药复方、中药单体及中药提取物作用于NLRP3炎症小体治疗炎症疾病的最新研究报道,以期为多种炎症疾病的发病机制及药物治疗的深入研究提供新思路.
Research status of anti-inflammatory effect of traditional Chinese medicine based on NLRP3 inflammatory body
Inflammasome is a kind of intracellular polyprotein complex,which is an important component of the complex system of local inflammatory microenvironment after human tissue damage.When the inflammasome is activated,it induces the activation of cysteine aspartate proteinase 1(caspase-1),mediates the maturation and secretion of proinflammatory cytokines,such as interleukin(IL)-1 β and IL-18,and induces cell death,which plays an important role in regulating the host immune response to pathogen infection and tissue repair of cell damage.Nod-like receptor protein 3(NLRP3)inflammatory body,which is composed of NLRP3,pro-cysteine aspartic acid specific protease-1(pro-caspase-1)and apoptosis-related spot-like protein(ASC),is the most deeply and widely studied type of inflammatory body,which plays an important role in the regulation of inflammation.When NLRP3 inflammatory bodies are activated,inflammatory mediators are produced and released,which participate in the occurrence and development of a variety of inflammatory diseases.Some studies have shown that traditional Chinese medicine can improve the pathological state of a variety of diseases by inhibiting NLRP3 inflammatory bodies,and play a role in the prevention and treatment of a variety of inflammatory diseases,including cardiovascular diseases,joint inflammation,diabetes and so on.This paper systematically combs the mechanism of NLRP3 inflammatory bodies,and summarizes the latest research reports on the effects of traditional Chinese medicine compound prescription,traditional Chinese medicine monomers and traditional Chinese medicine extracts on NLRP3 inflammatory bodies in the treatment of inflammatory diseases,in order to provide new ideas for the further study of the pathogenesis and drug treatment of many inflammatory diseases.

traditional Chinese medicineNod-like receptor protein 3 inflammasomeanti-inflammationmechanism

徐富梅、曾俊媛、赵磊、张启立、夏鹏飞、贾寅强、王洁、方鹏霞、续艳丽

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甘肃中医药大学药学院,甘肃兰州 730000

兰州市食品药品检验检测研究院,甘肃兰州 730000

西北中藏药省部共建协同创新中心,甘肃兰州 730000

陇药产业创新研究院,甘肃兰州 730000

甘肃省高校中藏药化学与质量研究省级重点实验室,甘肃兰州 730000

甘肃省道地药材质量标准化技术研究与推广工程实验室,甘肃兰州 730000

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中药 NOD样受体蛋白3炎症小体 抗炎 机制

国家自然科学基金国家自然科学基金甘肃省教育厅"双一流"科研重点基金甘肃省科技计划甘肃省道地药材质量标准化技术研究与推广工程实验室开放基金甘肃省药品科研基金

8216045781660577GSSYLXM-0521JR7RA564ddyc-2022-032023GSMPA078

2024

10.13699/j.cnki.1001-6821.2024.06.029

中国临床药理学杂志
中国药学会

中国临床药理学杂志

CSTPCD北大核心
影响因子：1.91
ISSN：1001-6821
年,卷(期)：2024.40(6)
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