Clinical trial of Vitapex paste combined with calcium hydroxide paste in root canal therapy patients
Objective To observe the clinical efficacy and safety of Vitapex paste and calcium hydroxide paste in the treatment of root canal patients.Methods Patients who received root canal treatment were included,and the data of patients who received one-time injection of calcium hydroxide pastefor root canal filling treatment were used as the control group;the data of patients who received Vitapex paste and calcium hydroxide paste for one-time filling injection root canal treatment at the same time were included as treatment group.The clinical efficacy,degree of pain,diameter of apical foramen,apical closure time,and detection of interleukin(IL)-1β,IL-8 and tumor necrosis factor-α(TNF-α)in gingival crevicular fluid between two groups of patients after 6 months were compared.Results There were 40 cases in control group and 42 cases in treatment group.After treatment,the total effective rates of treatment group and control group were 97.62％(41 cases/42 cases)and 80.00％(32 cases/40 cases),with significant difference(P＜0.05).After 6 months of treatment,36 patients in treatment group had no pain or mild pain,6 patients had moderate pain,and 0 patient had severe pain;there were 21 patients in control group who had no pain or mild pain,13 patients in moderate pain,and 6 patients in severe pain.The pain level in treatment group was significantly improved compared with control group,and the pain was reduced(P＜0.05).After 6 months of treatment,the diameter of the apical foramen and the closure time of treatment group were(0.55±0.22)mm and(13.86±2.05)month,which in control group were(0.81±0.10)mm and(16.98±4.35)month,the results of treatment group were significantly better than those in control group(all P＜0.05).After 6 months of treatment,IL-1 β,IL-8,TNF-α in the gingival crevicular fluid of treatment group were(12.50±2.18),(25.33±6.29)and(2.12±0.32)µg·L-1,which in control group were(23.00±6.00),(36.88±10.14)and(4.08±0.57)μg·L-1,all with significant difference(all P＜0.05).The drug complications in treatment group were 2 cases of gingival swelling,1 case of gingival pain.The control group had 3 cases of gingival swelling,2 cases of gingival pain,1 case of occlusal discomfort,respectively,with no statistically significant difference(P＞0.05).Conclusion The composite application of Vitapex paste and calcium hydroxide paste is more effective in treating root canals than a single calcium silicate bioceramic.
Vitapex pastecalcium hydroxide pasteroot canal therapydegree of painapex closure time
国家科技期刊平台
NSTL
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