内源性二氧化硫对血管的调控作用研究现状
Research status on the regulation of endogenous sulfur dioxide on blood vessels
宋运佳 1钟晴 1张蓉 1孙许涛1
作者信息
- 1. 黑龙江中医药大学基础医学院,黑龙江哈尔滨 150040
- 折叠
摘要
二氧化硫(SO2)参与调节血管多种生理过程,如维持正常血管结构、调节血管张力、控制血压、抑制血管平滑肌细胞增殖,调节其凋亡和自噬.在高血压、肺动脉高压和动脉粥样硬化等血管疾病中,SO2通过不同的分子机制对上述病理变化起到保护作用.本文将围绕内源性SO2的生成代谢、血管生物学效应及其对血管的调控作用进行综述.
Abstract
Sulfur dioxide(SO2)is involved in regulating various physiological processes of blood vessels,such as maintaining normal vascular structure,regulating vascular tension,controlling blood pressure,inhibiting vascular cell proliferation,regulating apoptosis and autophagy.In pathophysiological conditions such as hypertension,pulmonary hypertension and atherosclerosis,SO2 plays a protective role in pathological changes through different molecular mechanisms.In this paper,we will review the endogenous SO2 production and metabolism,vascular biological effects and its regulation on blood vessels.
关键词
二氧化硫/血管/高血压/肺动脉高压/动脉粥样硬化Key words
sulfur dioxide/blood vessel/high blood pressure/pulmonary hypertension/atherosclerosis引用本文复制引用
基金项目
国家自然科学基金(82204792)
中国博士后科学基金(2022M711089)
黑龙江省博士后基金(LBH-Z21080)
黑龙江省卫生健康委项目(20210202010178)
黑龙江省自然科学基金(YQ2022H020)
出版年
2024
国家科技期刊平台
NSTL
万方数据