中医药干预mTOR通路靶向自噬防治糖尿病肾病的研究现状
Research status of traditional Chinese medicine intervention in mTOR pathway targeting autophagy for prevention and treatment of diabetic nephropathy
杨世睿 1周婷婷 1马超超 1杨鹏斐 1牛凡琪 1杜雪洋 1闫丰喆 1王思农1
作者信息
- 1. 甘肃中医药大学中医临床学院,甘肃兰州 730000
- 折叠
摘要
糖尿病肾病(DKD)是糖尿病最重要的并发症之一.近年来,国内外研究发现,哺乳动物西罗莫司靶蛋白(mTOR)相关信号通路是参与自噬调节的一个经典通路,可通过靶向自噬途径达到治疗DKD的效果,在防治DKD中发挥着至关重要的作用.本文将主要从中医药干预mTOR相关信号通路靶向自噬防治DKD的作用机制做一综述,以期为临床防治DKD提供新的参考及依据.
Abstract
Diabetic kidney disease(DKD)is one of the most important complications of diabetes.In recent years,domestic and foreign studies have found that mammalian target protein of rapamycin(mTOR)related signaling pathway is a classic pathway involved in the regulation of autophagy,which can achieve the therapeutic effect of DKD by targeting the autophagy pathway,and plays a crucial role in the prevention and treatment of DKD.In this paper,we reviewed the mechanism of mTOR-related signaling pathway targeted autophagy in the prevention and treatment of DKD,in order to provide a new reference and basis for clinical prevention and treatment of DKD.
关键词
磷酸肌醇-3-激酶/蛋白激酶B/哺乳动物西罗莫司靶蛋白信号通路/腺苷酸活化蛋白激酶/哺乳动物西罗莫司靶蛋白信号通路/自噬/糖尿病肾病Key words
phosphoinositol 3 kinase/protein kinase B/mammalian rapamycin target pathway/adenosine monophosphate-activated protein kinase/mammalian target of rapamycin signaling pathway/autophagy/diabetic kidney引用本文复制引用
基金项目
甘肃省教育厅产业支撑计划(2021CYZC-03)
出版年
2024
国家科技期刊平台
NSTL
万方数据