长链非编码RNA在糖尿病周围神经病变发病机制中的研究现状
Research status on the pathogenesis of diabetic peripheral neuropathy by long chain non-coding RNAs
陈世婷 1梅英秀 1陈明珠 1杜联1
作者信息
- 1. 成都中医药大学基础医学院,四川 成都 611137
- 折叠
摘要
糖尿病周围神经病变(DPN)是一组累及周围神经系统的神经退行性疾病.长链非编码RNA(lncRNA)是机体正常生命活动以及疾病发生发展中重要的调控因子,广泛参与基因表达调控、表观遗传调节、转录及控制等生物学过程.近年来研究发现,lncRNA可通过参与DPN的代谢紊乱、氧化应激、神经炎症、血管受损、细胞自噬、细胞凋亡等发病机制,影响DPN的发生发展.本文对lncRNA在DPN发病机制中的调控作用进行阐述,以期为临床研究提供科学参考和新思路.
Abstract
Diabetic peripheral neuropathy(DPN)is a group of neurodegenerative diseases involving the peripheral nervous system.Long chain non-coding RNA(lncRNA)is an important regulatory factor in normal life activities and disease development,widely involved in gene expression regulation,epigenetic regulation,transcription and control and other biological processes.In recent years,a large number of studies have found that lncRNAs can affect the development of DPN by participating in the pathogenesis of DPN such as metabolic disorders,oxidative stress,neuroinflammation,vascular damage,cell autophagy,apoptosis and so on.This paper elaborates on the regulatory role of lncRNAs in the pathogenesis of DPN,with a view to providing scientific references and new ideas for clinical research.
关键词
长链非编码RNA/糖尿病周围神经病变/发病机制/代谢紊乱/氧化应激Key words
long chain non-coding RNA/diabetic peripheral neuropathy/pathogenesis/metabolic disorders/oxidative stress引用本文复制引用
基金项目
国家自然科学基金面上项目(81973585)
出版年
2024
国家科技期刊平台
NSTL
万方数据