首页|中医药调控有氧糖酵解防治肺癌的研究现状

中医药调控有氧糖酵解防治肺癌的研究现状

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  • 国家科技期刊平台
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有氧糖酵解(AEG)作为多种恶性肿瘤细胞能量代谢的主要途径,参与肺癌发生发展的全过程,在诱发肿瘤增殖、侵袭、转移等方面起到关键作用.中药单体及中药复方可以通过干预AEG途径,调控相关信号通路及关键蛋白酶、基因的表达,促进肺癌细胞凋亡,抑制AEG进程及肺癌细胞的增殖、生长,从而发挥抗肿瘤的作用.基于此,本文从AEG生物功能、调控肺癌机制及中药干预机制等方面进行归纳总结,以期为肺癌临床药物的开发提供新思路与科学依据.
Research status of regulating aerobic glycolysis by traditional Chinese medicine in prevention and treatment of lung cancer
Aerobic glycolysis(AEG),as the main pathway of energy metabolism of various malignant tumor cells,is involved in the whole process of the occurrence and development of lung cancer,and plays a key role in inducing tumor proliferation,invasion and metastasis.Traditional Chinese medicine monomers and compounds can regulate the expression of related signaling pathways and key proteases and genes by interfering with AEG pathway,promote the apoptosis of lung cancer cells,inhibit the AEG process and the proliferation and growth of lung cancer cells,and thus play an anti-tumor role.Based on this,this paper summarized the biological function of AEG,the mechanism of regulating lung cancer and the intervention mechanism of traditional Chinese medicine,in order to provide new ideas and scientific basis for the development of clinical drugs for lung cancer.

traditional Chinese medicineaerobic glycolysislung cancerresearch progress

张茂福、陈玉婵、宋忠阳、陈露露、赵海宏、张志明

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甘肃中医药大学中医临床学院,甘肃兰州 730000

甘肃中医药大学 附属医院 肿瘤内科,甘肃兰州 730020

甘肃省中医院肿瘤内科,甘肃兰州 730050

中医药 有氧糖酵解 肺癌 研究进展

甘肃省科技重大专项基金资助项目高端人才承担省级科技计划长江学者奖励计划国家中医药管理局全国名老中医药专家张志明传承工作室建设基金甘肃省中西医结合肿瘤临床医学研究中心基金资助项目甘肃省科技计划基金(重点研发计划)资助项目

甘科计[2022]1号-25甘科计[2021]20号-918JR2FA00122YF7FA

2024

10.13699/j.cnki.1001-6821.2024.13.028

中国临床药理学杂志
中国药学会

中国临床药理学杂志

CSTPCD北大核心
影响因子：1.91
ISSN：1001-6821
年,卷(期)：2024.40(13)
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