辐射对药代动力学的影响
Effects of radiation on pharmacokinetics
宗杰 1张海晖 1窦桂芳 1孟志云 1顾若兰 1吴卓娜 1朱晓霞 1胡瑄 1甘慧1
作者信息
- 1. 军事医学研究院辐射医学研究所,北京 100850
- 折叠
摘要
辐射主要来自医用射线、工业用射线、核废物和天然射线等,分为电离辐射和非电离辐射.研究电离和非电离辐射对药物代谢的影响,了解辐射后药物在机体内的吸收、分布以及辐射条件下消除快慢等情况,可对临床用药进行合理的指导.本文综述了辐射对不同药物的药代动力学的影响,阐述辐射状态下不同药代动力学参数的变化,并讨论变化产生的原因.
Abstract
Radiation mainly comes from medical radiation,industrial radiation,nuclear waste and atmospheric ultraviolet radiation,etc.,radiation is divided into ionizing radiation and non-ionizing radiation.Studying the effects of ionizing and non-ionizing radiation on drug metabolism,understanding the absorption and distribution of drugs in the body after radiation and the speed of elimination under radiation conditions can provide reasonable guidance for clinical medication.This article reviews the effects of radiation on the pharmacokinetics of different drugs,elaborates the changes of different pharmacokinetics under radiation state,and discusses the reasons for the changes.
关键词
药代动力学/辐射/动力学参数/药物代谢酶Key words
pharmacokinetics/radiation/dynamic parameter/drug metabolizing enzyme引用本文复制引用
基金项目
北京市自然科学基金资助项目(7202148)
出版年
2024
国家科技期刊平台
NSTL
万方数据