摘要
病毒性心肌炎(VMC)是扩张型心肌病的主要原因,可导致心力衰竭和心源性猝死.随着高通量测序技术的发展,非编码RNA(ncRNA)在VMC的发生发展中具有重要作用.ncRNA通过调节病毒复制、免疫细胞功能、心肌细胞死亡、心肌间质纤维化等病理过程促进VMC的发生发展.本文就ncRNA在VMC中的研究进展做一综述,为VMC的发病机制及诊疗提供新的思路.
Abstract
Viral myocarditis(VMC)is the leading cause of dilated cardiomyopathy,which can lead to heart failure and sudden cardiac death.With the development of high-throughput sequencing technology,non-coding RNA(ncRNA)plays an important role in the occurrence and development of VMC.ncRNA promotes the occurrence and development of VMC by regulating viral replication,immune cell function,myocardial cell death,myocardial interstitial fibrosis,and other pathological processes.This article reviews the research progress of ncRNA in VMC and provides new ideas for the pathogenesis,diagnosis,and treatment of VMC.
基金项目
甘肃省自然科学基金资助项目(21JR1RA027)
甘肃省自然科学基金资助项目(22JR5RA655)
国家科技期刊平台
NSTL
万方数据