铁死亡与肾纤维化相关性的研究现状
Research status of the correlation between ferroptosis and renal fibrosis
梁丽娟 1戴恩来 2白俊嫄 2刘灿 2丁昭然 2张杰2
作者信息
- 1. 甘肃中医药大学第一临床医学院,甘肃兰州 730100;甘肃中医药大学中西医结合学院,甘肃兰州 730100;敦煌医学与转化教育部重点实验室,甘肃兰州 730100
- 2. 甘肃中医药大学中西医结合学院,甘肃兰州 730100
- 折叠
摘要
肾纤维化是所有慢性肾病共同病理表现.铁死亡与肾纤维化发病密切相关,可以影响肾纤维化的发病,其是肾纤维化发生最关键的一步.本文阐述了铁死亡和肾纤维化关系,探讨铁死亡在肾纤维化的研究进展,并进一步总结、分析、阐述针对铁死亡的有效和高靶向性的中药天然活性成分,得出通过调控铁死亡关键靶点来逆转肾纤维化,以期为其在肾纤维化疾病预防和治疗领域前景提供广阔的新方向,为临床治疗提供科学的指导和依据.
Abstract
Renal fibrosis is a common pathological manifestation of all chronic kidney diseases.Ferroptosis is closely related to the pathogenesis of renal fibrosis and can influence the onset of renal fibrosis,and it is the most critical step in the development of renal fibrosis.The paper describes the relationship between ferroptosis and renal fibrosis,discusses the research progress of ferroptosis on renal fibrosis,and further summarizes,analyzes,and describes the effective and highly targeted natural active ingredients of traditional Chinese medicines against ferroptosis,and concludes that the reversal of renal fibrosis is achieved through the regulation of the key targets of ferroptosis,with a view to providing a broad new direction for its prospects in the field of renal fibrotic disease prevention and treatment;and to provide a scientific guide for clinical treatment and basis for clinical treatment.
关键词
铁死亡/肾纤维化/慢性肾病/发病机制/治疗Key words
ferroptosis/renal fibrosis/chronic kidney disease/pathogenesis/treatment引用本文复制引用
基金项目
国家自然科学基金资助项目(8216140859)
甘肃省高等学校创新基金资助项目(2022B-118)
敦煌医学与转化教育部重点实验室基金资助项目(DHXY20-08)
出版年
2024
国家科技期刊平台
NSTL
万方数据