Clinical trial of lurasidone hydrochloride and risperidone in patients with acute schizophrenia
Objective To observe the efficacy,cognitive function and safety of lurasidone hydrochloride in the treatment of acute schizophrenics.Methods Patients with acute schizophrenia were randomly divided into treatment group and control group.The treatment group was given lurasidone hydrochloride at the dosage of 40 mg on day 1,and 40-80 mg according to the need within 1 week,once a day.The control group received 4-6 mg·d-1 risperidone twice a day.The total observation lasted for 6 weeks.The positive and negative symptoms scales(PANSS)were performed at baseline,the 1st,the 2nd,the 4th and the 6th weekend of the treatment.Both groups were evaluated by Montreal cognitive assessment(MoCA)at baseline,and the 6th weekend.Compare the clinical efficacy and incidence of adverse drug reactions between the 2 groups of patients.Results 42 patients in the treatment group and 41 patients in the control group.The total effective rates for the treatment and control groups were 80.95％and 80.49％,respectively,with no statistically significant difference(P＞0.05).In treatment group and control group,at baseline,the total PANSS scores were 88.12±8.99 and 88.68±9.29,the MoCA scores were 20.48±2.65 and 20.24±2.85,respectively.At the 6th weekend of the treatment,the total PANSS scores were 55.90±11.14 and 54.68±13.34,the MoCA scores were 26.74±1.99 and 25.22±2.46,respectively,both were statistically different with those before treatment(all P＜0.01).MoCA scores were higher in the treatment group than those in the control group at the 6th weekend(P＜0.01).The incidences of adverse reaction in the treatment group and the control group were 30.95％and 56.10％,respectively,with significant difference(P＜0.05).Conclusion The efficacy of lurasidone hydrochloride and risperidone in the treatment of acute schizophrenia is equivalent.It is a kind of cognitive function well improved drug,as well as fewer adverse drug reactions,and well tolerated.
lurasidone hydrochloriderisperidoneacute schizophreniacognitive function
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