Hedgehog信号通路在肌少-骨质疏松症中的肌骨共生作用
Role of Hedgehog signaling pathway in muscle bone symbiosis in osteo-sarcopenia
刘晏东 1邓强 2李中锋 2彭冉东 2王雨榕 2李家明 2马平怡 1杜健强1
作者信息
- 1. 甘肃中医药大学研究生院,甘肃兰州 730000
- 2. 甘肃省中医院脊柱疾病诊疗中心,甘肃兰州 730050
- 折叠
摘要
本文阐述了肌少-骨质疏松症所涉及的肌肉和骨骼间的复杂串扰和密切联系及其发病机制,并概括性指出其治疗难点在于需要同时兼顾肌肉和骨骼.还阐述了 Hedgehog通路对于胚胎发育、组织形态建立以及人体组织的再生和修复的关键作用.从肌肉干细胞的增殖和分化、前体细胞和肌纤维生成、抑制炎症和调控免疫3个方面探讨了 Hedgehog通路对骨骼肌的重塑作用;从促进骨形成和抑制骨吸收2个方面阐述了 Hedgehog通路在骨重建中的作用.
Abstract
This article elaborates on the complex cross-talk and close relationship between muscles and bones involved in this disease,as well as its pathogenesis.It also summarizes that the difficulty of its treatment lies in the need to simultaneously consider both muscles and bones.And elaborated on the key role of the Hedgehog signaling pathway in embryonic development,tissue morphology establishment,and human tissue regeneration and repair.Investigated the remodeling effect of the Hedgehog signaling pathway on skeletal muscle from three aspects:Proliferation and differentiation of muscle stem cells,precursor cell and muscle fiber generation,inhibition of inflammation,and regulation of immunity;this article elucidates the role of the Hedgehog signaling pathway in bone reconstruction from two aspects.
关键词
Hedgehog信号通路/肌少-骨质疏松症/成肌/成骨/作用机制Key words
Hedgehog signaling pathway/muscle deficiency osteoporosis/myoblast/osteogenesis/mechanism of action引用本文复制引用
基金项目
甘肃省联合科研基金(23JRRA1534)
兰州市科技计划(2022-3-30)
出版年
2024
国家科技期刊平台
NSTL
万方数据