2型糖尿病胰岛β细胞损伤机制的研究现状
Research status of mechanisms of pancreatic islet beta cell injury in type 2 diabetes
翟艳会 1梁永林 1安冬 1张媛媛 1苏菲 1关晓文 1朱向东2
作者信息
- 1. 甘肃中医药大学基础医学院,甘肃兰州 730000
- 2. 宁夏医科大学中医学院,宁夏回族自治区银川 750004
- 折叠
摘要
2型糖尿病(T2DM)占所有糖尿病(DM)的90％以上,而胰岛β细胞质量下降与功能障碍是T2DM的核心环节,伴随病程延长β细胞数量功能逐渐衰减,其损伤机制涉及代谢应激、胰岛素分泌调节异常、胰岛微环境改变、线粒体损伤、糖脂毒性以及胰岛β细胞去分化等,因此对T2DM胰岛β细胞损伤机制进行总结阐述,以期对T2DM的精准干预提供参考依据.
Abstract
The number of type 2 diabetes(T2DM)accounts for more than 90％of all Diabetes mellitus(DM).The decrease of islet β cell mass and dysfunction are the core links of T2DM.With the prolongation of the course of disease,the number and function of β cells are gradually attenuated,and the damage mechanism has not been elucidated.At present,it is believed that it is closely related to metabolic stress,abnormal regulation of insulin secretion,changes in islet microenvironment,mitochondrial damage,glycolipid toxicity and dedifferentiation of islet β cells.Therefore,the mechanism of islet β cell damage in T2DM is summarized and elaborated in order to provide some reference for the precise intervention of T2DM.
关键词
2型糖尿病/胰岛β细胞/损伤机制Key words
type 2 diabetes/pancreatic β cells/damage mechanism引用本文复制引用
基金项目
甘肃省科技厅教育科技创新基金(2021CYZC-03)
宁夏回族自治区重点研发计划(2022BEG02034)
出版年
2024
国家科技期刊平台
NSTL
万方数据