Research status on the role of mitochondrial dysfunction in lipid metabolism in podocytes with diabetic kidney disease
Diabetic kidney disease(DKD),as a major causative agent of end-stage renal disease(ESRD),has a complex pathogenesis in which mitochondrial dysfunction and lipid metabolism disorders play key roles.Mitochondrial dysfunction leads to excessive reactive oxygen species(ROS)production,inhibits fatty acid β-oxidation,and creates lipotoxicity,which is the key to podocyte damage in DKD.Meanwhile,lipid metabolism disorder exacerbates ectopic accumulation of fat,activates inflammation and oxidative stress,and affects insulin signalling,which further inhibits mitochondrial function and drives DKD progression.Therefore,an in-depth understanding of the association between mitochondrial dysfunction and podocyte lipid metabolism in DKD is important for DKD treatment.This review discusses the basic profiles of DKD,mitochondrial dysfunction,and podocyte lipid metabolism,and their interactions,as well as discussing the current status of the DKD treatment,with a view to providing references for the research and treatment of DKD.
国家科技期刊平台
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