Clinical trial on the use of ω-3 fish oil fat milk in the treatment of total parenteral nutrition after radical resection of gastric cancer
Objective To explore the application effect of ω-3 fish oil fat emulsion in total parenteral nutrition(TPN)after radical resection of gastric cancer.Methods Patients with gastric cancer undergoing radical resection in the hospital were divided into control group and treatment group.The patients in the control group were treated with TPN after operation,and the energy was mainly glucose and conventional fat emulsion.The daily calorie supply was 100-125 kJ·kg-1,and the deep venous catheter was dripped for 10-12 h.On the basis of the control group,the patients in the treatment group were added with ω-3 fish oil fat emulsion 100 mL,and the daily calorie supply and infusion conditions were the same as those in the control group.Both groups were treated for 7 days.All patients were treated for 7 d.The nutritional status(total protein,transferrin,albumin,nitrogen balance),gastrointestinal function recovery,immune function[CD4+/CD8+,natural killer(NK)cells],inflammatory factors[interleukin-6(IL-6),IL-12p70,tumor necrosis factor-α(TNF-α)]in abdominal drainage fluid and the safety was evaluated.Results There were 40 cases in treatment group and 42 cases in control group,respectively.After treatment,total response rates in treatment group and control group were 90.00％(36 cases/40 cases)and 71.43％(30 cases/42 cases),and the difference was statistically significant(P＜0.05).In the two groups,total protein,transferrin and albumin decreased at 3 d after surgery,but they all increased at 7 d after surgery,and nitrogen balance increased after surgery.There was no significant difference in total protein,transferrin,albumin or nitrogen balance between the two groups at different time periods(all P＞0.05).The first exhaust time in treatment group and control group were(55.72±9.75)and(61.52±10.43)h.At 7 d after surgery,proportions of peripheral blood CD4+/CD8+levels in treatment group and control group were 1.50±0.38 and 1.29±0.30;proportions of NK cells were(19.64±3.04)％and(17.24±2.96)％;IL-6 levels in drainage fluid were(18.77±4.69)and(32.36±5.18)pg·mL-1;IL-12p70 levels were(6.14±1.86)and(8.93±2.17)pg·mL-1;TNF-α levels were(25.62±4.95)and(30.75±4.88)pg·mL-1,the differences were statistically significant(all P＜0.05).During treatment,main adverse drug reactions included vomiting,nausea and persistent abdominal distension in treatment group,while main adverse drug reactions included vomiting,nausea and persistent abdominal distension in control group.There was no significant difference in total incidence of adverse drug reactions between treatment group and control group(20.00％vs 26.19％,P＞0.05).Conclusion ω-3 fish oil fat emulsion can enhance immune function,reduce inflammatory response,abdominal drainage volume and promote postoperative rehabilitation in patients with gastric cancer.
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