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天蚕素A及其衍生物生物活性的研究现状

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近年来,天然抗菌肽成为新型抗生素开发的一个重要方向.天蚕素具有抗菌谱广、耐受性好、低药物不良反应等特点.天蚕素A作为天蚕素家族中第1个被发现的抗菌肽,具有多种重要的生物活性.该文通过查阅相关文献资料,对近年来天蚕素A及其衍生物在抗细菌、抗真菌、抗寄生虫、抗肿瘤等生物活性方面的研究进行综述,展望了其应用前景,以期为天蚕素的进一步研究和开发提供参考依据.
Research status on bioactivity of Cecropin A and its derivatives
In recent years,natural antimicrobial peptides have become an important direction in the development of novel antibiotics.Cecropin has the characteristics of wide antibacterial spectrum,good tolerance and low adverse drug reactions.As the first antimicrobial peptide discovered in the family of Cecropin,Cecropin A has many important biological activities.In this paper,the research on the antibacterial,antifungal,antiparasitic and antitumor activities of Cecropin A and its derivatives in recent years was reviewed,and its application prospect was prospected,in order to provide reference for further research and development of cecropin.

Cecropin Aantibacterialantifungalantiparasiticanticancer

晁镜茹、苏春丽、莫金秋、李春苗、李欣、廖洪利

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成都医学院药学院,四川成都 610500

成都医学院公共卫生学院,四川成都 610500

塔里木大学医学院,新疆维吾尔自治区阿拉尔 843300

天蚕素A 抗菌 抗真菌 抗寄生虫 抗肿瘤

2024

中国临床药理学杂志
中国药学会

中国临床药理学杂志

CSTPCD北大核心
影响因子:1.91
ISSN:1001-6821
年,卷(期):2024.40(19)