The activation of microglia is the central link in the development of cognitive dysfunction in sepsis-associated encephalopathy,which causes a series of chain reactions.Autophagy was closely related to the activation of microglia.It can regulate neuroinflammatory response through a variety of mechanisms and affect the pathophysiological process of patients with sepsis-associated encephalopathy(SAE).This article reviews the regulatory mechanism of autophagy on microglia activation in SAE and the strategies for the treatment of SAE,in order to complete the clinical transformation and find new diagnosis and treatment ideas as soon as possible.
关键词
脓毒症相关脑病/小胶质细胞活化/自噬/信号通路/应用
Key words
sepsis-associated encephalopathy/activation of microglia/autophagy/singaling pathway/apply
维普
万方数据