Ferroptosis is regulatory cell death driven by iron dependence and lipid peroxidation,which is closely related to iron,lipid and amino acid metabolism,and is also affected by a variety of signaling pathways.Recent studies have shown that ferroptosis plays an important role in the occurrence and development of myocardial ischemia-reperfusion injury(MIRI).MIRI is a phenomenon involving a variety of cellular pathophysiological processes and cellular signaling pathways,which often occurs after adverse cardiovascular events such as acute myocardial infarction,coronary heart disease,and cardiac arrest and resuscitation.Traditional Chinese medicine has unique advantages in the treatment of MIRI due to its natural source and efficacy.This article reviews the role of ferroptosis in the pathological links of MIRI and the research status of traditional Chinese medicine intervention with ferroptosis as the target,in order to provide new ideas and methods for the prevention and treatment of MIRI from the perspective of ferroptosis.
关键词
中医药/铁死亡/心肌缺血再灌注损伤
Key words
traditional Chinese medicine/iron death/myocardial ischemia-reperfusion injury
维普
万方数据