摘要
胃癌前病变(PLGC)是胃黏膜"炎-癌"转化过程中的关键病理阶段,尽早诊断、有效干预该阶段对预防胃癌发生具有积极意义.诸多研究证实,中药可以通过调控细胞增殖和凋亡、调节炎症反应、抗血管生成、抑制上皮-间充质转化、抑制糖酵解、抗氧化应激、抗幽门螺杆菌、调节自噬水平、调节肠道菌群等不同途径对PLGC发挥有效干预作用.本文通过系统阐述中药单体或提取物、中药复方干预PLGC作用机制的研究现状,旨在为本病的临床治疗和相关药物研发提供参考.
Abstract
Precancerous lesions of gastric cancer(PLGC)is a key pathological stage in the process of inflammation cancer transformation of the gastric mucosa.Early diagnosis and effective intervention in this stage have positive significance in preventing the occurrence of gastric cancer.Numerous studies have confirmed that traditional Chinese medicine can effectively intervene in PLGC by regulating cell proliferation and apoptosis,regulating inflammatory response,anti angiogenesis,inhibiting epithelial mesenchymal transition,inhibiting glycolysis,antioxidant stress,combating helicobacter pylori,regulating autophagy levels,and regulating gut microbiota through various pathways.The article systematically elaborates on the research status of the intervention mechanism of traditional Chinese medicine monomers or extracts,and traditional Chinese medicine formulas in PLGC,aiming to provide reference for the clinical treatment of this disease and related drug development.
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