Tacrolimus is the first immunosuppressive choice for organ transplantation.It is also used in the immunotherapy of many non-transplant diseases.Because of its large individual variabilities and narrow treatment window,the individualized administration for tacrolimus taking advantage of population pharmacokinetics is necessary.This article aims to summarize population pharmacokinetics studies of tacrolimus in patients with non-transplant diseases and its influencing factors,and to provide a reference for rational use of tacrolimus.
关键词
他克莫司/群体药代动力学/儿童/非移植性疾病/个体化用药
Key words
tacrolimus/population pharmacokinetics/non-transplant diseases/personalized medicine
维普
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