Pathogens composition,characteristics of drug resistance and risk factors of pulmonary infection in elderly patients with chronic bronchitis
Objective The aim of this study was to explore pathogens composition,characteristics of drug resistance and risk factors of pulmonary infection in elderly patients with chronic bronchitis(CB).Methods A total of 112 elderly patients with CB admitted to Internal Medicine Department of the hospital were retrospectively studied between January 2020 and December 2022.According to presence or absence of pulmonary infection,they were divided into infection group(46 cases)and non-infection group(66 cases).The sputum samples from infection group were collected for culture and identification of pathogens.The drug resistance of main pathogens was analyzed,and the risk factors of pulmonary infection were analyzed by logistic regression analysis.Results The incidence of pulmonary infection in elderly patients with CB was 41.07%.There were 53 strains of pathogens,including 31 strains of Gram-negative bacteria,17 strains of Gram-positive bacteria and 5 strains of fungi(58.49%,32.08%,9.43%).In Gram-negative bacteria,drug resistance rates of Escherichia coli and Klebsiella pneumoniae were high to cefotaxime,cefzolin,cotrimoxazole and ampicillin(70.12%,68.33%,70.55%,88.23%;58.75%,53.84%,58.75%,95.35%),drug resistance rates of Acinetobacter Baumannii were high to ceftazidine,cefepime,piperacillin and gentamicin(73.33%,66.67%,73.33%,73.33%),and drug resistance rates of Pseudomonas aeruginosa were high to ampicillin and cefotaxime(66.67%,66.67%).In Gram-positive bacteria,resistance rates of Staphylococcus aureus and Enterococcus were high to gentamicin,penicillin,ciprofloxacin and levofloxacin(66.67%,80.00%,73.33%,80.00%;73.33%,83.33%,66.67%,66.67%),but their resistance to vancomycin was very low.There were significant differences in age,course of disease,diabetes mellitus,invasive operation,long-term bed rest,hypoproteinemia and APACHE II scores between infection group and non-infection group(P<0.05),but there was no significant difference in gender,BMI,drinking history,hypertension,coronary heart disease or hospitalization time(P>0.05).The results of logistic regression analysis showed that age,course of disease,diabetes mellitus and invasive operation were independent risk factors of pulmonary infection in elderly patients with CB(P<0.05).Conclusion The distribution of pathogens was extensive in elderly patients with CB and pulmonary infection.There were significant differences in drug resistance of different pathogens.Age,course of disease,diabetes mellitus and invasive operation were all independent risk factors of pulmonary infection.
万方数据
维普
