Correlation between serum calcium with prognosis during hospitalization in patients with acute coronary syndrome
Objective To investigate the correlation between admission serum calcium and prognosis in patients with acute coronary syndrome (ACS) during hospitalization.Method The 675 ACS patients who were admitted to the Department of Cardiovascular Medicine,at Beijing Tiantan Hospital,Capital Medical University between June 1st,2019 and December 31st,2019 were enrolled in the present study. Serum calcium was measured at admission. And adverse events were recorded during hospitalization. The correlation between admission serum calcium and prognosis during hospitalization was analyzed.Result The adverse events were occurred in 29 ACS patients. The patients were divided into four groups,group Q1(serum calcium concentration<2.20 mmol/L),group Q2 (2.20～2.26 mmol/L),group Q3 (>2.26～2.32 mmol/L),and group Q4 (>2.32 mmol/L). The patients in group Q1 were older,had a higher incidence of acute myocardial infarction and adverse events during hospitalization,and showed a higher troponin I (cTnI) and B-type natriuretic peptide (BNP) as compared with group Q3 and Q4 (P<0.05). Serum albumin and phosphorus were lower in group Q1 than in group Q3 and Q4 (P<0.05). Pearson correlation analysis showed that serum calcium was negatively associated with age,BNP,cTnI and GRACE score (P<0.05) and positively with serum albumin,glucose and lipid (P<0.05). Logistic regression analysis found that lower serum calcium level (OR=0.008,95％CI 0.000～0.559) was an independent predictor for adverse events during hospitalization in ACS patients after adjustment for potential confounders (P<0.05). Receiver operating characteristic curves showed that the area under curve was 0.727(0.612～0.841) when serum calcium was used to predict adverse events during hospitalization.The cut-off value was 2.135mmol/L. The sensitivity was 48.3％ and the specificity was 92.3％.Conclusion Lower admission serum calcium is correlated with adverse events in ACS patients during hospitalization. Serum calcium has the efficacy of predicting adverse events during hospitalization in ACS patients,with high predicted specificity but high misdiagnosis rate,which can be combined with other indicators to improve the prediction effect.
万方数据
维普
