Literature analysis of immune checkpoint inhibitor-induced pancreatitis
AIM To analyze the patterns and characteristics of immune checkpoint inhibitor-induced pancreatitis,and to provide reference for clinical safety in medication.METHODS Case reports on immune checkpoint inhibitor-related pancreatitis published internationally from August 2015 to December 2022 were retrieved and analyzed.RESULTS A total of 25 pieces of literature involving 25 cases with a male-to-female ratio of 4∶1 were retrieved.The average age was(61.92±12.23)years old,and the onset of symptoms often occurred more than 6 weeks after immune checkpoint inhibitor treatment.Clinical manifestations primarily included abdominal pain,back pain,nausea,vomiting,diarrhea and fever.Laboratory examinations revealed elevated levels of amylase and lipase and imaging features showed diffuse pancreatic enlargement and peripancreatic fat infiltration.Among the cases,20 patients improved after treatment,4 patients died after treatment and the outcome of 1 patient was not mentioned.CONCLUSION There is a risk of mortality in pancreatitis.Therefore,vigilance and proactive management for the occurrence of pancreatitis throughout the entire course of immune checkpoint inhibitor therapy are essential.
immune checkpoint inhibitorpancreatitisadverse drug reaction
国家科技期刊平台
NSTL
万方数据
