ω-3多聚不饱和脂肪酸类药物影响维持性血液透析患者微炎症反应的Meta分析
Meta-analysis of the effects of ω-3 polyunsaturated fatty acids on microinflammatory responses in maintenance hemodialysis patients
王诗涵 1王顺 1李媛媛 1陈海霞 1杨文君1
作者信息
- 1. 新疆医科大学第一附属医院肾脏病中心,乌鲁木齐 830054
- 折叠
摘要
目的 探讨ω-3多聚不饱和脂肪酸(ω-3 PUFAs)类药物对维持性血液透析患者微炎症反应的影响.方法 检索PubMed、Web of Science和Cochrane Library等数据库,筛选并提取2011年1月至2023年12月ω-3 PUFAs类药物对维持性血液透析患者微炎症反应影响的随机对照试验(RCTs)研究,应用Review Manager 5.4软件进行Meta分析.结果 共纳入9篇RCTs研究.在降低维持性血液透析患者的C反应蛋白方面,ω-3 PUFAs治疗组与对照组比较差异有统计学意义[MD=-2.73,95％CI(-4.18,-1.29),Z=3.72,P=0.000 2];在降低白细胞介素-6方面,2组比较差异无统计学意义[MD=-13.97,95％CI(-21.58,-6.36),Z=3.60,P=0.22];在降低肿瘤坏死因子-α方面,2组比较差异有统计学意义[MD=-9.37,95％CI(-14.46,-4.28),Z=3.61,P=0.000 3].结论 ω-3 PUFAs可以明显改善维持性血液透析患者的微炎症反应.
Abstract
AIM To investigate ω-3 polyunsaturated fatty acids(ω-3 PUFAs)on the micro inflammatory response in maintenance hemodialysis patients.METHODS Databases such as PubMed,Web of Science,and Cochrane Library were retrieved for randomized controlled trials(RCTs)from January 2011 to December 2023.A Meta-analysis was performed using Review Manager 5.4 software.RESULTS A total of 9 RCTs were included.In term of reducing C-reactive protein in patients undergoing maintenance hemodialysis,there was a statistically significant difference between theω-3 PUFAs treatment group and the placebo control group[MD=-2.73,95％CI(-4.18,-1.29),Z=3.72,P=0.000 2].There was no statistically significant difference in reducing interleukin-6(IL-6)[MD=-13.97,95％CI(-21.58,-6.36),Z=3.60,P=0.22].The difference in tumor necrosis factor-α(TNF-α)levels between 2 groups was statistically significant[MD=-9.37,95％CI(-14.46,-4.28),Z=3.61,P=0.000 3].CONCLUSION In patients on maintenance hemodialysis,ω-3 PUFAs can significantly improve the microinflammatory response.
关键词
ω-3多聚不饱和脂肪酸/维持性血液透析/微炎症反应/Meta分析Key words
ω-3 polyunsaturated fatty acids/maintenance of hemodialysis/microinflammatory reaction/Meta-analysis引用本文复制引用
基金项目
临床专科人才专业能力创新应用科研项目(RCLX2315094)
国家自然科学基金(81960132)
出版年
2024
国家科技期刊平台
NSTL
万方数据