Effect of aripiprazole in the treatment of alcoholism-induced mental disorder based on the changes of sIL-2R level and cognitive function
AIM To explore the influence of aripiprazole on efficacy of patients with alcoholism-induced mental disorders based on the changes of serum soluble interleukin-2 receptor(sIL-2R)and cognitive function.METHODS A total of 124 patients with alcoholism-induced mental disorders in the hospital were divided into group A and group B by random number table method,with 62 cases in each group.Group A was given routine treatment,and group B was treated with aripiprazole at an initial dose of 10 mg·d-1 and gradually increased to 30 mg·d-1.The clinical efficacy and mental symptoms,levels of serum-related cytokines[interleukin-2(IL-2),sIL-2R],cognitive function and quality of life before and after treatment were compared between 2 groups.The correlation between serum sIL-2R level and the above indicators in group B after treatment was analyzed.RESULTS The scores of positive symptom,negative symptom and general psychopathology in group B after treatment were(10.04±2.98),(8.12±1.37)and(21.56±2.71)points,all of which were lower than the scores in group A(13.81±2.24),(13.73±2.01)and(26.74±3.12)points in group A,with significant differences(P＜0.05).After treatment,the number of correct responses and the number of completed classifications in group B were more than those in group A while the number of incorrect responses was less than that in group A,with significant differences(P＜0.05).The total clinical efficacy in group B was better than that in group A(P＜0.05).After treatment,the levels of serum IL-2 and sIL-2R in group B were(25.41±3.85)and(72.61±8.10)pg·mL-1,which were lower than those in group A(31.26±4.08)and(89.43±8.26)pg·mL-1(P＜0.05).After treatment,the level of serum sIL-2R in group B was positively correlated with the scores of positive and negative symptoms scale and the number of incorrect responses(P＜0.05),and was negatively correlated with the number of correct responses,the number of completed classification and all scores of items of quality of life(P＜0.05).In group B,serum sIL-2R level after treatment was negatively correlated with clinical efficacy(P＜0.05).CONCLUSION Aripiprazole has significant efficacy in the treatment of alcoholism-induced mental disorder,which can effectively reduce the level of serum sIL-2R and improve the cognitive function and quality of life of patients,and the level of serum sIL-2R is closely related to the clinical efficacy,mental symptoms,cognitive function and quality of life of patients.
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