基于高质量循证用药指南制定与实施的临床药学"实践-研究一体化"模式构建与实践
Construction and practice of the"practice-research integration"mode for clinical pharmacy based on the development and implementation of high-quality evidence-based medication guidelines
宋再伟 1赵荣生 1陈耀龙 2徐东3
作者信息
- 1. 北京大学第三医院药学部,北京 100191;北京大学医学部药物评价中心,北京 100191;北京大学治疗药物监测和临床毒理学中心,北京 100191
- 2. 中国医学科学院循证评价与指南研究创新单元,兰州大学基础医学院,兰州 730000;甘肃省循证医学重点实验室,兰州 730000
- 3. 南方医科大学卫生管理学院卫生管理系Acacia实施科学实验室,广州 510515;南方医科大学世界卫生组织研究中心,广州 510515
- 折叠
摘要
目的 探索基于高质量循证用药指南制定与实施的临床药学"实践-研究一体化"模式,助推临床药学学科建设.方法 阐述高质量循证用药指南制定与实施过程,构建临床药学"实践-研究一体化"模式,并以《中国大剂量甲氨蝶呤循证用药指南》为例探讨实践过程.结果 建立了"合理用药临床研究-药物循证评价研究-循证用药指南制定-指南实施性研究"的研究体系,凝练出"循证药学证据生态系统"的特色学科发展方向,探索出临床药学B-E-P(Bedside-Evidence-Practice)的"实践-研究一体化"模式.基于《中国大剂量甲氨蝶呤循证用药指南》实施,临床药师成功解救了1例大剂量甲氨蝶呤治疗后出现严重排泄延迟及急性肾损伤的患者.结论 实施以高质量循证用药指南为基础的临床药学"实践-研究一体化"模式,可助力提升药师药学服务能力,提高临床药物治疗水平,并促进临床药学学科建设与发展.
Abstract
AIM To explore the"practice-research integration"mode of clinical pharmacy based on the formulation and implementation of high-quality evidence-based medication guidelines,and boost the construction of clinical pharmacy discipline.METHODS The formulation and implementation process of high-quality evidence-based medication guidelines was explained,the"practice-research integration"mode of clinical pharmacy was established,and the practice process of the"Evidence-based guideline of medication therapy of high-dose methotrexate"was discussed as an example.RESULTS A research system of"clinical research of rational drug use-drug evidence-based evaluation research-evidence-based medication guideline formulation-guideline implementation research"was established,the characteristic discipline development direction of"evidence-based pharmacy evidence ecosystem"was summarized,and the"practice-research integration"mode of clinical pharmacy B-E-P(Bedside-Evidence-Practice)was explored.Based on the"Evidence-based guideline of medication therapy of high-dose methotrexate",the clinical pharmacist successfully rescued a patient with severe excretion delay and acute kidney injury after high-dose methotrexate treatment.CONCLUSION The implementation of the"practice-research integration"mode of clinical pharmacy based on high-quality evidence-based medication guidelines can contribute to enhancing pharmacists'pharmaceutical service capabilities,improving the professional level of clinical drug therapy,and promoting the construction and development of clinical pharmacy discipline.
关键词
指南制定/指南实施/临床药学/循证药学/证据生态系统Key words
guideline formulation/guideline implementation/clinical pharmacy/evidence-based pharmacy/evidence ecosystem引用本文复制引用
基金项目
国家自然科学基金资助项目(72304007)
国家自然科学基金资助项目(72074005)
中央高校基本科研业务费资助项目(BMU2022XY004-01)
出版年
2024
国家科技期刊平台
NSTL
万方数据