Effect of lamotrigine and sodium valproate on thyroid hormone and BDNF and CRP in patients with depressive episodes of bipolar disorder
AIM To explore the effects of lamotrigine and sodium valproate on thyroid hormone,brain-derived neurotrophic factor(BDNF)and C-reactive protein(CRP)in patients with depressive episodes of bipolar disorder.METHODS According to the inclusion and exclusion criteria,100 patients with bipolar depressive episodes from April 2021 to April 2023 were selected and randomly divided into control group and observation group,with 50 patients in each group.The control group was treated with sodium valproate,and the observation group was treated with lamotrigine combined with sodium valproate.The clinical efficacy,Hamilton rating scale for depression(HAMD-24)score,BDNF level,CRP level,thyroid hormone levels and adverse reactions of 2 groups were observed and compared.RESULT After treatment,the total effective rate of observation group was significantly higher than that of control group(P＜0.05).After treatment,compared with the control group,the HAMD-24 score and TSH value were lower in the observation group,and the T3 and T4 values were higher(P＜0.05).Compared with the control group,after treatment,the level of BDNF in the observation group was higher and the level of CRP was lower(P＜0.05).After treatment,there was no significant difference in the total incidence of adverse reactions between 2 groups(P＞0.05).CONCLUSION Combination of lamotrigine with sodium valproate in patients with depressive episodes of bipolar disorder improves treatment adherence,improves clinical symptoms,promotes a rise in thyroid hormone and BDNF levels,and decreases CRP level,which is worthy of clinical promotion.
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