Efficacy of nifedipine combined with ritodrine hydrochloride in the treatment of premature rupture of membranes based on generalized estimation equation and its influence on serum TLR4,HMGB1 and α1AT levels
Efficacy of nifedipine combined with ritodrine hydrochloride in the treatment of premature rupture of membranes based on generalized estimation equation and its influence on serum TLR4,HMGB1 and α1AT levels
AIM To explore the efficacy of nifedipine combined with ritodrine hydrochloride based on generalized estimation equation in the treatment of premature membranes and the effects on serum toll-like receptor 4(TLR4),high mobility group protein B1(HMGB1)and α1-antitrypsin(α1AT)levels.METHODS The study subjects were 163 patients with premature rupture of membranes treated in our hospital from October 2022 to October 2023,who were divided into observation group(78 patients)treated with nifedipine combined with ritodrine hydrochloride and control group(85 patients)treated with ritodrine hydrochloride according to different administration methods.There were 60 pregnant women in both groups after 1∶1 matching with propensity score matching method.The therapeutic effect,extended gestation time,success rate of fetal protection,neonatal outcome,serum TLR4,HMGB1 and α1AT levels were compared in 2 groups after matching.The factors influencing treatment effectiveness were analyzed.RESULTS The observation group was superior to the control group in terms of treatment effect,prolonging pregnancy,success rate of fetal protection and neonatal outcome(P＜0.05).The effects of the 2 treatments on serum TLR4,HMGB1 and α1AT levels of pregnant women with premature rupture of membranes were evaluated by generalized evaluation equation.After administration,serum TLR4,HMGB1 and α1AT levels of pregnant women in both groups were decreased(P＜0.05),the serum levels of TLR4,HMGB1 and α1AT in observation group were lower than those in control group.The analysis of influencing factors showed that serum TLR4 levels＜55 ng·mL-1,HMGB1 levels＜7.3 ng·mL-1,and α1AT levels＜2.75 ng·L-1 prior to treatment were significantly associated with effective treatment outcomes(P＜0.05).CONCLUSION Nifedipine combined with Ritodrine hydrochloride is more resultful in treating premature rupture of membranes,and the serum levels of TLR4,HMGB1 and α1AT are lower.The effect of nifedipine combined with ritodrine hydrochloride on premature rupture of membranes is better than that of ritodrine hydrochloride alone,which can prolong pregnancy and improve the success rate of fetal protection.TLR4,HMGB1 and α1AT may be potential targets for treating premature rupture of membranes.
关键词
胎膜早破/硝苯地平/盐酸利托君/Toll样受体4/高迁移率族蛋白B1/α1-抗胰蛋白酶
Key words
premature rupture of membranes/nifedipine combined with ritodrine hydrochloride/toll-like receptor 4/high-mobility group box-1/oxidized alpha-1 antitrypsin
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