Drug-drug interactions of antimicrobial agents in patients with mycoplasmal pneumonia based on pharmaceutical information database
AIM To evaluate the drug-drug interactions(DDIs)of antimicrobial agents used in the treatment of mycoplasmal pneumonia(MP)and provide management recommendations for appropriate clinical drug use.METHODS A comprehensive search was conducted in 3 drug information databases(Micromedex,Lexicomp,and DDlnter)to retrieve information on DDIs involving antimicrobial agents used in the guidelines for MP.Each drug was queried individually,and the results were analyzed.RESULTS Multiple interactions were found for all 11 antimicrobial agents for treating MP in the 3 databases.Macrolide antibiotics exhibited a higher number of DDIs,requiring particular attention when used concomitantly with medications for patients with comorbidities such as diabetes and hyperlipidemia.Tetracycline antibiotics necessitated consideration of interactions with antiepileptic drugs,and caution was advised when using formulations containing metal cations.Quinolone antibiotics should be monitored for potential DDIs with anticoagulants and acid-suppressing medications.When necessary,treatment regimens should be adjusted,and appropriate monitoring of clinical indicators should be implemented.CONCLUSION DDIs may occur frequently in patients with multiple comorbidities and concurrent use of multiple medications.It is essential for clinicians and pharmacists to adjust treatment regimens and provide appropriate monitoring to avoid adverse drug reactions or treatment failure due to DDIs,thereby promoting rational drug use in clinical practice.
国家科技期刊平台
NSTL
万方数据
