Analysis of monitoring results of vancomycin AUC0-24h in elderly patients
AIM To explore the application and clinical significance of AUC0-24h as the target of vancomycin monitoring in elderly patients.METHODS The clinical data of 265 elderly patients who met the inclusion criteria were collected retrospectively,and the infection diagnosis,vancomycin use and AUC0-24h compliance were analyzed.RESULTS Among 265 elderly patients,35.1％of the AUC0-24h monitoring results were within the target range(400-650 mg·h·L-1),and 55.1％were below the target range.There was no statistically significant difference in the rates of reaching the standard of AUC0-24h of different administration schemes(P＞0.05).When analyzed by stratified groups based on different creatinine clearance rates,the differences in the rates of reaching the standard of AUC0-24h were statistically significant(P＜0.05).The AUC0-24h compliance rate of the groups with creatinine clearance rate＜30 mL·min-1 and 30-39.99 mL·min-1 was higher.For the elderly patients with creatinine clearance rate ≥ 40 mL·min-1,the rate of reaching the standard of AUC0-24h was about 30％.CONCLUSION The compliance rate of vancomycin AUC0-24h in elderly patients in our hospital is low.Clinical pharmacists can provide pharmaceutical services through therapeutic drug monitoring to optimize the vancomycin administration plan of clinical treatment.
国家科技期刊平台
NSTL
万方数据
