Objective We aim to investigate the risk factors related to peri-operative weight loss and analyze the interaction between changes in body composition and those risk factors.Methods A total of 89 participants who visited the Department of General Surgery for planned gastrointestinal surgeries in Tianjin Union Medical Center from December 2019 to May 2020 were enrolled.Skeletal muscle area and fat area in CT images at L3 level were measured and compared between groups with and without weight loss.The relationships between weight loss(especially the changes in body composition)and lipid metabolism,nutritional status,clinical outcomes and medical costs were analyzed through logistic regression.Results Univariate analysis found patients with weight loss had a lower serum pre-albumin level(P=0.014),a higher serum cholesterol level(P=0.002),a higher prevalence rate of digestive system carcinoma(P=0.003)and a higher proportion of patients with lymphatic infiltration(P=0.046).Multiple logistic regression showed that serum cholesterol level was a risk factor for peri-operative weight loss(OR=1.711,95％CI:1.036 to 2.824,P=0.036).In particular,there was a significant correlation between cholesterol level and skeletal muscle mass(r=-0.591,P=0.016).Moreover,multivariate analysis showed an impact of higher serum cholesterol level on the clinical outcomes in surgical patients.Conclusions A higher cholesterol level is related with decreased body mass,especially skeletal muscle mass.Furthermore,weight loss had adverse effects on the clinical outcomes of surgical patients.
Perioperative weight lossCholesterolSurgerySkeletal muscle mass
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