Study on the Mechanism of Aronia melanocarpa Fruit Treating Diabetes Mellitus Type Ⅱ Based on Network Pharmacology
To investigate the mechanism of action of Aronia melanocarpa Fruit on diabetes mellitus type Ⅱ using a network pharmacological approach.Methods:Venn analysis was performed by combining the Swiss Target Predic-tion database to obtain potential targets of action for AMF and the GeneCards database to obtain potential targets of action for T2DM.Build the"active ingredient-disease-target"network viewable diagram with Cytoscape 3.7.2 software.Establish Protein Interaction Network(PII)using the STRING 11.0 database.GO and KEGG pathway en-richment analysis of intersecting targets was performed through the DAVID 6.8 database.Results:A review of the literature yielded 19 AMF active ingredients,649 relevant targets,785 T2DM disease-related targets,and 82 inter-secting targets.KEGG pathway enrichment analysis was obtained for 103 pathways.The active ingredients and their mechanism of action of black chokeberry the treatment of diabetes mellitus type Ⅱ were predicted,providing a theo-retical basis for further research on Aronia melanocarpa Fruit the treatment of type Ⅱ diabetes.
Aronia melanocarpa FruitDiabetes mellitus type ⅡNetwork pharmacology
国家科技期刊平台
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