Strategies for Thermostability and Substrate Specific Modification of Zearalenone Degrading Enzymes
Zearalenone(Zen)and its derivatives are one of the mycotoxins with a wide range of contamination,and widely exist grains and their byproducts,(such as corn,barley,wheat,sorghum et al.),posing a serious threat to animal and human health.The degradation and removal of ZEN and its derivatives by biotechnology will be the ma-jor method to solve the pollution of ZEN in the future.However,it is currently known that ZEN degrading enzyme has poor thermal stability and low catalytic efficiency,and difficult to meet the requirements of industrial production.In this paper,the modification strategies with protein engineering for improving the thermal stability and substrate speci-ficity of ZEN degrading enzymes were reviewed,and the research advance and problems of the ZEN degrading en-zymes were elucidated to provide reference for the development of engineering modification of ZEN degrading enzymes.
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