Causal relationship between gut microbiota and alopecia areata:a bidirectional two-sample Mende-lian randomization study
Objective:To determin the relationship between gut microbiota and alopecia areata,and to provide reference for early prevention and disease improvement of alopecia areata.Methods:The study select-ed significant SNPs associated with gut microbiota as instrumental variables and used the inverse variance weighted(IVW)method as the primary analysis method for assessing causal effects.Heterogeneity of the ge-netic instrumental variables was evaluated with Cochran's Q test,and pleiotropy was assessed with the MR-Egger intercept test and the MR-PRESSO test.Sensitivity of the causal relationship between SNPs and alope-cia areata was evaluated using the leave-one-out approach.Results:The inverse variance weighted method showed that the Lachnospiraceae family group 3-1-46FAA,Dialister genus,Paraprevotella genus,Rumino-coccus genus lactaris group,Dialister invisus group,and the PWY.6731 pathway microbiota were negatively correlated with alopecia areata;the PWY0.1415 pathway microbiota,Bacteroidetes phylum,Bacteroidales or-der,Bacteroidia class,Bacteroides genus caccae group,and PWY.5686 pathway microbiota were positively correlated with alopecia areata;Mendelian randomization results showed a positive correlation between alopecia areata and the Bacteroidales order,Bacteroidia class,and Bacteroidetes phylum;Sensitivity analysis:The MR-Egger intercept test and MR-PRESSO test indicated no horizontal pleiotropy,and the heterogeneity test showed no heterogeneity in their relationship,with the leave-one-out analysis yielding robust results.Conclu-sion:The gut microbiota of Bacteroides were associated with alopecia areata.
万方数据
维普
