中国麻风皮肤病杂志2025,Vol.41Issue(1) :55-57.DOI:10.12144/zgmfskin202501055

青少年男性大疱性系统性红斑狼疮一例

Bullous systemic lupus erythematosus in an adolescent male:a case report

邓诗音 罗雅琪 刘雅芹 谢映霞 陈留鑫 蔡艳霞
中国麻风皮肤病杂志2025,Vol.41Issue(1) :55-57.DOI:10.12144/zgmfskin202501055

青少年男性大疱性系统性红斑狼疮一例

Bullous systemic lupus erythematosus in an adolescent male:a case report

邓诗音 1罗雅琪 1刘雅芹 1谢映霞 1陈留鑫 1蔡艳霞2
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作者信息

  • 1. 广东医科大学附属医院皮肤科,广东 湛江,524000;广东医科大学,广东 湛江,524000
  • 2. 广东医科大学附属医院皮肤科,广东 湛江,524000
  • 折叠

摘要

大疱性系统性红斑狼疮(BSLE)为SLE的一个独特亚型,发病机制与针对Ⅶ型胶原的自身抗体显著相关,多累及 20~40 岁的年轻女性.本文报道 1 例青少年男性BSLE,该病例患者对糖皮质激素、JAK抑制剂、免疫调节剂、免疫球蛋白治疗均反应不佳,但氨苯砜治疗有显著改善.

Abstract

Bullous systemic lupus erythematosus(BSLE)is a unique variant of SLE,characterized by its pathogenesis being notably linked to autoantibodies that target typeⅦcollagen.The disease predominantly im-pacts young women aged between 20 and 40 years.This paper reports a young male diagnosed patient with BSLE who exhibited a suboptimal response to treatments such as glucocorticoids,Janus kinase(JAK)inhibi-tors,immunomodulators,and immunoglobulin therapy.However,the patient experienced a significant im-provement following administration of dapsone.

关键词

大疱性系统性红斑狼疮/水疱/氨苯砜

Key words

bullous systemic lupus erythematosus/bullae/dapsone

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出版年

2025
中国麻风皮肤病杂志
中国麻风防治协会,山东省皮肤病性病防治研究所

中国麻风皮肤病杂志

影响因子:0.302
ISSN:1009-1157
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