A 69-year-old female patient was diagnosed with multiple myeloma(MM)three months ago.Exposure to cold weather triggered symptoms such as purpura,ecchymosis,joint swelling,and pain in her ex-tremities.Her serum light chain kappa levels were notably elevated.Protein fixation electrophoresis positive for monoclonal immunoglobulin IgG,monoclonal kappa light chain(κ),and cryoglobulinemia test.Consequent-ly,secondary type Ⅰ cryoglobulinemia was diagnosed.Given the association between the patient's MM and cryoglobulinemia,the hematology department adjusted the chemotherapy regimen,a topical mucopolysaccha-ride polysulfate cream was applied to the affected skin areas additionally,and efforts were made to keep her acra warm.After two months,the patient's ecchymosis completely resolved.
维普
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