首页|继发于多发性骨髓瘤的Ⅰ型冷球蛋白血症一例

继发于多发性骨髓瘤的Ⅰ型冷球蛋白血症一例

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患者,女,69 岁.3 个月前确诊多发性骨髓瘤(multiple myeloma,MM),后因天气寒冷诱发四肢末端紫癜、瘀斑伴关节肿痛.检查示血清轻链kappa 显著升高,蛋白固定电泳提示单克隆免疫球蛋白IgG阳性,单克隆kappa轻链(κ)阳性,冷球蛋白血症试验阳性,诊断为继发Ⅰ型冷球蛋白血症.考虑患者冷球蛋白血症与MM疾病活动有关,血液科予以更换化疗方案,局部皮肤外用多磺酸粘多糖乳膏,注意肢端保暖.2 个月后患者瘀斑完全消退.
Type Ⅰ cryoglobulinemia secondary to multiple myeloma:a case report
A 69-year-old female patient was diagnosed with multiple myeloma(MM)three months ago.Exposure to cold weather triggered symptoms such as purpura,ecchymosis,joint swelling,and pain in her ex-tremities.Her serum light chain kappa levels were notably elevated.Protein fixation electrophoresis positive for monoclonal immunoglobulin IgG,monoclonal kappa light chain(κ),and cryoglobulinemia test.Consequent-ly,secondary type Ⅰ cryoglobulinemia was diagnosed.Given the association between the patient's MM and cryoglobulinemia,the hematology department adjusted the chemotherapy regimen,a topical mucopolysaccha-ride polysulfate cream was applied to the affected skin areas additionally,and efforts were made to keep her acra warm.After two months,the patient's ecchymosis completely resolved.

multiple myelomatype Ⅰ cryoglobulinemiavasculitis

黄雪沂、郑结成、程云龙、谭敏、廖家

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中山市第二人民医院,广东 中山,528447

多发性骨髓瘤 Ⅰ型冷球蛋白血症 血管炎

2025

中国麻风皮肤病杂志
中国麻风防治协会,山东省皮肤病性病防治研究所

中国麻风皮肤病杂志

影响因子:0.302
ISSN:1009-1157
年,卷(期):2025.41(1)