摘要
阿普米司特是一种通过抑制磷酸二酯酶-4(PDE4)发挥作用的小分子药物,已在我国获批治疗斑块状银屑病.笔者以"apremilast"为关键词对PubMed数据库进行检索,并对银屑病关节炎、白塞病、白癜风、斑秃、化脓性汗腺炎和特应性皮炎的随机对照试验数据,以及该药应用于特应性皮炎、Hai-ley-Hailey病、化脓性汗腺炎、皮肌炎、系统性硬化症、慢性光化性皮炎及坏疽性脓皮病等疾病的病例报道进行了综述,为该药在皮肤科的应用提供借鉴.
Abstract
Apremilast,a small molecule that acts by inhibition of the phosphodiesterase-4 enzyme,has been approved for the management of plaque psoriasis in China.Utilizing'apremilast'as a keyword in the ti-tle,the PubMed database was searched for randomized controlled trial data on psoriatic arthritis,Behçet's dis-ease,vitiligo,alopecia and hidramatitis,and case reports of atopic dermatitis,Hailey-Hailey disease,hidra-denitis suppurativata,dermatomyositis,systemic sclerosis,chronic actinic dermatitis and pyoderma gangreno-sum treated with apremilast.Then we summarized the retrieved literature offering a reference for clinical prac-tice.
维普
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