Apremilast,a small molecule that acts by inhibition of the phosphodiesterase-4 enzyme,has been approved for the management of plaque psoriasis in China.Utilizing'apremilast'as a keyword in the ti-tle,the PubMed database was searched for randomized controlled trial data on psoriatic arthritis,Behçet's dis-ease,vitiligo,alopecia and hidramatitis,and case reports of atopic dermatitis,Hailey-Hailey disease,hidra-denitis suppurativata,dermatomyositis,systemic sclerosis,chronic actinic dermatitis and pyoderma gangreno-sum treated with apremilast.Then we summarized the retrieved literature offering a reference for clinical prac-tice.
维普
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