摘要
目的：评价樟脑 油精喷剂的药效及其在使 用中的安全性。方法：将樟脑油精涂于裸露皮肤上，进行驱蚊试验 ；取白色念球菌（ATCC10231）悬液加入樟脑油精，观察对真菌的 抑制作用；急性经口毒性试验采用一次性灌胃给药；急性皮肤刺激和眼刺激试验直接涂药于 家兔皮肤和滴药于眼结膜囊内。结果：驱蚊保护时间达6h以上；抑 菌率达99.99%;小鼠 急性经口LD50为1 302.25mg/kg；对家兔皮肤刺激积分值为0，48h后对眼刺激平 均指数为0.5。结论：本品对蚊虫有一定驱避保护作用，对霉菌 生长有较强的抑制作用，而且毒性低，使用安全。
Abstract
Objective:To evaluate repellent efficacy,fun gistatic efficacy and saf ety of the camphor oil spray.Method:Place the human volunt eer's hand treated with the camphor oil inside a cage containing 300 Aedes alb opictus,for 2 min, and observe the treated skin surface for mosquit oes which landed and attempted to feed. Mingle the camphor oil and the fungous s uspension,Candida albicans,culture and count the number of mold.Infuse the m ice with the spray by single oral injection,and treat directly the rabbits' expo sed skin and the conjunc tiva crypt with the spray.Result:The repellent protection time against Aedes albopictus was over 6h. Mean fungistatic rate to mold was 99.99%. The acute oral LD50 was 1 302.5mg/kg in mice. This produc t was non-irritant to skin,but slightly irritant to eye. Conclusion: The camphor oil spray is a better repellency against mosquito,inhibit or against mold,and low acute toxicity substance.
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维普
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