Rickettsia japonica and Japanese spotted fever:A review on the pathogen and disease
Japanese spotted fever(JSF)is a commonly neglected infectious disease,and misdiagnosis and treatment delay are pivotal determinants of adverse outcomes among JSF patients.This paper reviews the genetic and evolutionary characteristics,transmission routes,and hosts of the pathogen Rickettsia japonica as well as the epidemiology,clinical manifestations,laboratory examination,and response strategy of JSF.Although progress has been made in the epidemiological study of this deadly infectious disease in China,information on the nationwide distribution of JSF and tick vectors is lacking.It is necessary to strengthen epidemiological investigation of JSF and surveillance of the hosts and vectors across the country,so as to provide a basis for the prevention and control and clinical diagnosis of the disease.
Rickettsia japonicaJapanese spotted feverEpidemiologyCurrent status research