A serological survey of infection with Severe fever with thrombocytopenia syndrome virus in rural residents and host animals in Dongyang,Zhejiang Province
Objective To investigate the prevalence of infection with Dabie bandavirus,also know as Severe fever with thrombocytopenia syndrome virus(SFTSV),in rural residents and host animals in Dongyang,Zhejiang Province,China,and analyze its influencing factors,so as to provide a theoretical basis for the control of the epidemic of severe fever with thrombocytopenia syndrome(SFTS).Methods Three townships with reported SFTS cases were selected,and another three townships with similar topographic features but without case reports were selected by 1:1 matching.Two villages were selected from each township as the study area to collect serum samples from residents and host animals.Human serum samples were tested for SFTSV antibodies by enzyme-linked immunosorbent assay,while animal serum samples were tested by double antigen sandwich assay.SPSS 18.0 software was used to analyze the data.The Chi-square test was used for rate comparison.A logistic regression analysis was performed to determine risk factors.Results A total of 1 117 rural residents were examined,of whom 22 were positive for SFTSV antibodies,with a positive rate of 1.97%.There were no significant differences in the positive rate of SFTSV antibodies between sexes,ages,and occupations(all P>0.05).According to the logistic regression analysis,the potential risk factors for SFTSV infection included previous reports of SFTS cases in villages of residence(odds ratio[OR]=2.994,95%confidence interval[CI]:1.277-7.021,P<0.05)and a history of tick bites in the last five years(OR=3.563,95%CI:1.227-10.342,P<0.05).The positive rates of SFTSV antibodies of sheep,dogs,cattle,and pigs were 45.83%(11/24),7.69%(3/39),0(0/7),and 0(0/20),respectively,showing a significant difference between them(χ2=23.559,P<0.001).Among 183 rodents tested,1 was positive for SFTSV antibodies.Conclusions In some rural areas of Dongyang,SFTSV antibodies were detected in both residents and animal hosts,and the antibody detection rate was higher in areas with reported cases than in those without case reports,suggesting that the prevalence of SFTSV infection in Dongyang exceeds expectations.In addition to tick control,future SFTS prevention and control efforts should also focus on strengthening animal management,health promotion and education,and rodent control.
Severe fever with thrombocytopenia syndromeSevere fever with thrombocytopenia syndrome virusDabie bandavirusHostSerologyAntibody
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