Confirmation and investigation of the first suspected case of human granulocytic anaplasmosis in Tianshui,Gansu Province
Objective To investigate the characteristics of the first case of human granulocytic anaplasmosis in Tianshui,Gansu Province,China,so as to provide a scientific basis for the prevention and control of human granulocytic anaplasmosis.Methods From July to August 2022,an epidemiological survey was performed on a suspected case of human granulocytic anaplasmosis in Tianshui and the case's living environment,livestock,and tick infestations.Quantitative real-time PCR was used to detect Anaplasma phagocytophilum antigens in the blood and ticks collected from the case and the living environment.Results The case had fever,fatigue,and headache,with a decreased white blood cell count(1.00×109/L),a decreased platelet count(46×109/L),and increased levels of aminotransferases.The tick and whole blood from the patient were positive for the nucleic acid of A.phagocytophilum and negative for the nucleic acids of Dabie bandavirus and rickettsiae.The patient was not sensitive to conventional symptomatic medications,but was cured after treatment with quinolones(levofloxacin).Conclusions This case was confirmed as tick-borne human granulocytic anaplasmosis.It is necessary to further carry out investigations of natural foci of tick-borne Anaplasma and strengthen the capabilities of detecting and monitoring vector-borne pathogens at primary medical institutions in Tianshui.
Human granulocytic anaplasmosisEpidemiologyInvestigationTianshui
陈秋梅、王珍妍、张涛、刘水、张平、熊志军、马燕东、王热勤、管斌、XIONG Hui
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天水市疾病预防控制中心病媒防制科,甘肃 天水 741000
天水市中西医结合医院,甘肃 天水 741020
天水市麦积区疾病预防控制中心,甘肃 天水 741020
Department of Vector Control,Tianshui Center for Disease Control and Prevention,Tianshui,Gansu 741000,China
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