Clinical features of severe fever with thrombocytopenia syndrome and risk factors
Objective To investigate the clinical features of patients with severe fever with thrombocytopenia syndrome(SFTS)of different severity levels and risk factors affecting the severity of SFTS,so as to provide a reference for the clinical diagnosis and treatment and prevention of the disease.Methods The clinical data of 75 patients with laboratory-confirmed SFTS hospitalized in the department of infectious diseases and department of intensive care medicine of every hospital were collected in Tai'an,Shandong Province,China from March 2013 to November 2019.According to the specific criteria,these patients were divided into non-critical group and critical group.Clinical features and clinical indicators were compared between the two groups.Continuous data were compared using the independent t test and Mann-Whitney U test.Categorical data were compared using the Chi-square test or Fisher's exact test.Risk factors were determined by using binary logistic regression analysis and receiver operating characteristic(ROC)curves method.Results The critical group differed significantly from the non-critical group in terms of 20 indexes,including age,the length of hospital stay,chills,bleeding symptoms,dyspnea,nervous system symptoms,alanine aminotransferase,aspartate aminotransferase,lactate dehydrogenase,creatine kinase-MB,prothrombin time,activated partial thromboplastin time(APTT),thrombin time(TT),creatinine,total protein,albumin,potassium,sodium,chlorine,and calcium(all P<0.05).Multivariable logistic regression analysis detected statistical significance in APTT[odds ratio(OR)=1.082(1.024～1.143),χ2=7.839,P=0.005]and TT[OR=1.171(1.017～1.348),χ2=4.814,P=0.028].The areas under the ROC curves for APTT and TT were 0.826 and 0.771,respectively(both P<0.001).Conclusions Prolonged APTT and TT are main risk factors affecting the severity of SFTS.For patients at risk,early identification,intervention,and treatment can help reduce their mortality.
Severe fever with thrombocytopenia syndromeCritical caseClinical featureRisk factor
万方数据
维普
