Relationship between serum parameters and the severity of hemorrhagic fever with renal syndrome
Objective To investigate the value of serum procalcitonin(PCT)and albumin(ALB)in predicting the severity of hemorrhagic fever with renal syndrome(HFRS).Methods A retrospective analysis was performed on the clinical and laboratory data of 21 adult patients with HFRS,involving white blood cells(WBC),platelets(PLT),PCT,ALB,and activated partial thromboplastin time(APTT).The t-test or Mann-Whitney U test was used to compare the differences in the levels of WBC,PLT,PCT,ALB and APTT in different disease severity groups.Spearman rank correlation(for skewed distribution data),Pearson correlation(for normal distribution data),binary logistic regression were used to analyze the statistical power of PCT and ALB in predicting the severity of HFRS.Results Compared with those in the mild group,the levels of WBC,PCT,and ALB in the severe group were significantly higher(all P<0.05),with no significant differences in the levels of PLT and APTT between the two groups(both P>0.05).The disease severity was positively correlated with WBC(r=0.471,P=0.031)and PCT(rs=0.819,P<0.001)and negatively correlated with ALB(rs=-0.801,P<0.001).There were no significant correlations between PLT and the severity of the disease,and between APTT and the severity(both P>0.05).In the severe group,PCT and ALB levels were independently correlated with the disease severity[OR=7.812,95%confidence interval(CI):1.579-38.655,P=0.012;OR=0.713,95%CI:0.546-0.932,P=0.013].Conclusion Serum PCT and ALB levels are independent risk factors reflecting the severity of HFRS,showing high clinical value as early warning parameters to assess the severity of HFRS.
Hemorrhagic fever with renal syndromeProcalcitoninAlbumin
NETL
NSTL
万方数据
