Objective To explore the relationship between age,serum inflammatory factors and prolonged hospitalization in patients with AECOPD,to construct a scoring system based on age and serum inflammatory factors,and to evaluate it's predictive ability.Methods The clinical information of three hundred and ninety-one patients with AECOPD admitted to the affiliated Hospital of North China University of Science and Tech-nology from October 2020 to October 2022 were retrospectively analyzed.According to the average hospital stay of 16 days in AECOPD,the patients were divided into a standard-length group(n=260)and an over-time group(n=131).The independent risk factors associated with AECOPD were screened out to construct a scoring system.Results Age,hs-CRP,SA A and PCT were independent risk factors for prolonged hospi-talization of AECOPD patients in the AECOPD standard length group and overtime length group,while WBC,NEU,FIB and ESR were not independent risk factors for prolonged hospitalization of AECOPD pa-tients.According to the maximum principle of the Jorden index,the critical value of prediction was screened and Kappa value was calculated.The area under the curve(AUC)of the model was 0.899.Sensitivity was 82.4%,and specificity was 86.2%.Kappa value was 0.669,which had a good predictive value and calculation result.Conclusion The established scoring system for predicting prolonged hospitalization of AECOPD pa-tients has a certain accuracy,and early identification and intervention of high-risk patients in this kind of pa-tients has a certain guidance and application value for clinicians'decision-making.