Pharmacological analysis and medication rules of myocardial ischemia based on data mining and network pharma-cology
Objective To analyze the medication law and pharmacological analysis of traditional Chinese medi-cine in the treatment of myocardial ischemia through data mining and bioinformatics.Methods With"myo-cardial ischemia"as the theme word,the relevant literature was collected and the prescription was analyzed.The drugs with the highest frequency were taken as the objects of network pharmacology analysis.The tcmsp analysis platform was used to build the corresponding active ingredient and target database,and OMIM,TTD and gencards databases were used to predict the disease-related target genes.Venn was used to take the inter-section of the corresponding drug group and the disease target,and the intersection target was imported into the STRING database to construct the protein interaction network,and the PPI network was imported into Cytoscape 39.0 software to screen the core target,and the"drug-active ingredient-target"interaction network was constructed at the same time.The metascape database was used for go enrichment analysis and KEGG signaling pathway enrichment analysis,and the visualization processing was carried out in the wechat.Results Two hundred and thirty-four cases of eligible literature were included,and the distribution of TCM syn-drome types was Qi deficiency and blood stasis syndrome(56);According to the analysis of high-frequency drugs,Astragalus membranaceus(159),Angelica sinensis(138)and Codonopsis pilosula(127)have the highest frequency.The drug targets are mostly focused on tonifying deficiency,activating blood circulation and removing blood stasis,and the drug properties are mainly warm;Pungent and sweet herbs are the most popular;Meridians mainly belong to liver,lung and heart meridians;Nineteen pharmaceutical ingredients were screened in tcmsp database,and quercetin,luteolin,paeoniflorin and isoliquiritigenin ranked high ac-cording to the degree value;The core targets of traditional Chinese medicine in the treatment of myocardial ischemia were selected as PI3K,Aktl,IL6,VEGF by the enrichment analysis of go and KEGG pathways.The drug treatment of myocardial ischemia mainly involved in biological processes such as the response to ox-idative stress and apoptosis,as well as signaling pathways such as apoptosis signaling pathway and iron death signaling pathway.Conclusion Traditional Chinese medicine may act on PI3K,Aktl,IL6,VEGF through quercetin,luteolin and other components to regulate the response of oxidative stress and apoptotic signaling pathway in the treatment of myocardial ischemia.
Data miningTraditional Chinese medicineMyocardial ischemiaMedication rulesPharmacological analysis
NETL
NSTL
万方数据
