Objective Analyzing the moral cognition and aggressive behavior changes in patients with schizo-phrenia.Methods From March 2022 to June 2023,three hundred and ninety-one patients with schizophrenia were recruited from the inpatient and outpatient departments of Beijing Anding Hospital,Capital Medical U-niversity,and 410 healthy individuals were matched and recruited.The Mini International Neuropsychiatric Interview(MINI 7.0.2)was used to assess both patients and healthy individuals.The Moral Foundations Questionnaire(MFQ)and the Moral Identity Measure(MIM)were employed to evaluate the moral cognition levels of the two groups of research subjects.The Buss-Perry Aggression Questionnaire(AQ-CV)was uti-lized to assess the aggressiveness levels of both groups,and the Childhood Trauma Questionnaire(CTQ)was additionally administered to evaluate the childhood trauma experiences of the two groups.Independent sample t-tests and Multivariate Analysis of Variance(MANOVA)were applied to compare the differences in the va-rious indicators between the two groups of research subjects.Results There were no statistically significant differences were observed in demographic data such as gender,age,and years of education between the two groups of research subjects(P＞0.05).Univariate analysis revealed that patients with schizophrenia had sig-nificantly lower moral cognition scores and higher aggression scores compared to healthy individuals(P＜0.001).Additionally,schizophrenia patients were found to have significantly more childhood trauma experi-ences(F=72.520,P＜0.001),a history of more aggressive behaviors(X2=27.920,P＜0.001),and more instances of being left behind(X2=15.510,P＜0.001).Covariance analysis,after controlling for covariates,continued to demonstrate impairment in moral cognition among patients with schizophrenia[MFQ was(92.66±26.64)vs.(114.49±26.14),F=111.660,P＜0.001;MIM was(62.40±15.53)vs.(67.42±11.62),F=9.430,P=0.002],and a tendency for aggression to be increased was noted(60.49±25.25)vs.(54.52±20.67),(F=3.440,P=0.064).Stratified analysis demonstrated that under conditions of childhood trauma,the moral foundation of schizophrenia patients was lower than that of healthy individuals(91.85±26.87)vs.(110.23±32.29),(F=15.740,P＜0.001).The dimensions of hostility(16.02±7.27)vs.(13.23±5.15),(F=5.88,P=0.016)and self-directed aggression(10.38±5.30)vs.(8.50±3.71),(F=4.990,P=0.026)were also found to be higher in schizophrenia patients.In the absence of childhood trauma,the moral foundation of schizophrenia patients remained significantly lower than that of healthy individuals(94.43±25.46)vs.(115.00±25.30),(F=79.990,P＜0.001).Conclusion Com-pared with healthy people,patients with schizophrenia have more traumatic childhood experiences,impaired moral cognition,and increased aggression.
维普
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