Correlation of plasma exosomal miR-3614 expression and MRI-related parameters with the progression of cervical cancer following concurrent chemoradiotherapy
Objective The benefit of concurrent chemoradiotherapy for cervical cancer patients varies widely,and there is a lack of clinical indicators to reflect the efficacy.This study aimed to investigate the relationship of plasma exosomal microRNA-3614(miR-3614)expression and MRI-related parameters with the progres-sion of cervical cancer following concurrent chemoradiotherapy.Methods A total of one hundred and thirty-eight cervical cancer patients admitted to the North China University of Science and Technology Affiliated Hospital between March 2020 and February 2023 were selected.Prior to the initial concurrent chemoradio-therapy,real-time fluorescence quantitative PCR was utilized to assess miR-3614 levels in plasma exosomes,while MRI parameters were recorded.Patients were followed up to identify risk factors for progression fol-lowing concurrent chemoradiotherapy for cervical cancer.Results The median age of the patients was 55(49,61)years.There were 41 patients with International Federation of Gynecology and Obstetrics(FIGO)StageⅡB and 97 patients with Stage Ⅲ.The median follow-up duration for all patients was 33(19,37)months,during which 41 cases(29.71％)experienced progression post concurrent chemoradiotherapy.COX regres-sion analysis employing the Forward:LR method revealed that,following adjustment for the FIGO stage,tumor diameter,slow apparent diffusion coefficient(ADC),volume transfer constant,and extravascular ex-tracellular volume ratio,lymph node metastasis(HR=5.451,95％CI:2.691～11.043,P＜0.001)and miR-3614 levels exceeding 2.55(HR=4.168,95％CI:1.872～9.281,P＜0.001)emerged as independent risk factors for progression post concurrent chemoradiotherapy.Conversely,ADC levels surpassing 0.52 X 10-3mm2/s(HR=0.377,95％CI:0.172～0.826,P=0.015)and perfusion-related volume fraction(f)excee-ding 0.23(HR=0.307,95％CI:0.124～0.763,P=0.011)were identified as independent protective factors.Conclusion The study findings suggest an association between plasma exosomal miR-3614,lymph node me-tastasis,ADC,and f with the progression of cervical cancer following concurrent chemoradiotherapy.
万方数据
维普
