Objective Exploring the effect of recombinant human epidermal growth factor combined with cal-cium hydroxybenzenesulfonate on visual function recovery after cataract phacoemulsification.Methods One hundred and six patients who underwent phacoemulsification in Shijiazhuang People's Hospital from January 2018 to February 2023 were selected for research.They were divided into experimental group and control group using a lottery method,with 53 cases in each group.The control group received calcium dobesylate treatment,while the experimental group received recombinant human epidermal growth factor combined with calcium dobesylate treatment.The best corrected visual acuity(BCVA),intraocular pressure,preoperative and postoperative tear film rupture time(BUT)were compared at 1-week,1-month,and 6-month after sur-gery Tear secretion test(SIT),membrane fluorescence staining(FL),macular fovea retinal thickness(CSMT),total macular volume(TMV),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),nitric oxide(NO)levels,and comparison of drug adverse reactions and incidence of macular edema.Results In the two groups,the recovery of BCVA at 1-month and 6-month after operation was better than that at 1-week after operation,and the intraocular pressure was lower than that at 1-week after operation.The recov-ery of BCVA at 6-months after operation was better than that at 1-month,and the intraocular pressure was lower than that at 1-week after operation.The recovery of BCVA was better than that of the control group at 1-week,1-month and 6-months after operation,and the intraocular pressure was lower than that of the con-trol group(P＜0.05).There was no significant difference in preoperative BUT,SIT and FL between the two groups(P＞0.05).One month after operation,BUT and FL were lower than those before operation,and SIT was higher than that before operation(P＜0.05).Compared with the control group,the BUT and FL in the experimental group were lower and the SIT was higher(P＜0.05).There was no significant differ-ence in the incidence of macular edema between the two groups(P＞0.05).There was no significant differ-ence between CSMT and TMV before operation(P＞0.05).One month after operation,the CSMT of the two groups was lower than that before operation,and that of the experimental group was lower than that of the control group(P＜0.05).The TMV of both groups increased after operation,and the increasing range of the experimental group was lower than that of the control group(P＜0.05).There was no significant differ-ence in the preoperative levels of VEGF,ET-1 and NO between the two groups(P＞0.05).1-month after operation,the levels of ET-1 in the two groups were significantly lower than those before operation,while the levels of VEGF and NO in the experimental group were lower than those in the control group,while the levels of VEGF and NO were higher than those in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combi-nation of calcium ISobenesulfonate and recombinant human epidermal growth factor in phacoemulsification of cataract can significantly promote postoperative visual acuity recovery,reduce the impact on tear film,and improve macular status,with high safety.
Recombinant human epidermal growth factorCalcium hydroxybenzenesulfonateCata-ract phacoemulsificationVisual function
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