Correlation between dyslipidemia prevalence and all-cause mortality in urban and rural elderly in Beijing
Objective To understand the prevalence,awareness,treatment and control of dyslipidemia among the urban and rural elderly in Beijing,explore the relationship between dyslipidemia and all-cause death,and provide the scientific basis for lipid management of urban and rural elderly in Beijing.Methods The data were from the baseline and follow-up data of Beijing Elderly Comprehensive Health Cohort Study(BECHCS).The multi-stage cluster sampling method was used to select 2 102 urban elderly from Wanshou Road in Haidian district in 2009 and 2 397 rural elderly from Miyun district of Beijing in 2014 as the subjects,respectively.A total of 4 499 older adults were included in the study.The investigation was conducted with the questionnaire,physical examination and laboratory test.The x2 test and multivariate logistic regress were used to analyze the data.The multivariate Cox proportional risk model was used to analyze the effect of dyslipidemia on all-cause death.Results The average age of 4 499 subjects was(70.5±6.8)years old.The morbidity rates of elevated total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and decreased high density lipoprotein cholesterol(HDL-C)were 12.09％,14.34％,11.22％,and 9.27％,respectively;the rates of morbidity,awareness,treatment,and control of dyslipidemia were 40.30％,45.67％,23.50％,and 14.73％,respectively.The multivariate logistic regress results showed that the risk in elderly with female(OR=1.7 89),educational level≥junior middle school(OR=1.375),overweight(OR=1.890),obesity(OR=2.449),hypertension(OR=1.399),diabetes(OR=1.466),blood uric acid 200-419 μmol/L(OR=1.487)and ≥420 μmol/L(OR=2.660)and living in urban(OR=1.920)was much higher(P＜0.05).The multivariate Cox proportional risk model analysis results showed that after adjusting possible confounding factors,the decreased HDL-C could significantly increase the risk of all-cause mortality in elderly(HR=1.286,95％CI:1.017-1.627).There was not significant influence of elevated TC(HR=0.946,95％CI:0.744-1.203),elevated TG(HR=1.067,95％CI:0.849-1.341),elevated LDL-C(HR=0.985,95％CI:0.769-1.262)and total dyslipidemia(HR=0.996,95％CI:0.843-1.176)on all-cause death in elderly(P＞0.05).Conclusion The dyslipidemia morbidity among urban and rural elderly in Beijing was higher,while the rates of awareness,treatment,and control were lower.It should take the intervention and management for reducing HDL-C level of elderly to reduce the risk of all-cause mortality.
DyslipidemiaMorbidityAwareness rateTreatment rateControl rateCohort study
NETL
NSTL
万方数据
