Correlation between serum uric acid level and all-cause death risk among urban and rural elderly in Beijing
Objective To explore the correlation between baseline serum uric acid(SUA)level and the risk of all-cause death in urban and rural elderly in Beijing,and provide the scientific basis for the correlation between the elderly SUA level and the all-cause death risk.Methods The data were from the Beijing Elderly Comprehensive Health Cohort Study(BECHCS).From September 2009 to June 2010 and from June to September 2014,the two-stage random sampling method was used to select elderly residents(≥ 60 years old)from Wanshou Road in Haidian district and Jugezhuang town and Miyun county of Beijing,respectively as the subjects.The investigation was performed with questionnaire,physical examination and laboratory test;and it took 2 to 3 years to follow up once.Following-up ended on March 31,2021.A total of 4 471 people were included in the study,including 2 075 urban residents and 2 396 rural residents.According to the diagnostic criteria(SUA level＞420 μmol/L)of hyperuricemia,the subjects were divided into non-hyperuricemia group(4 104 cases)and hyperuricemia group(367 cases).The rank sum test and x2 test were used to analyze the data,and Cox proportional hazard regression model was used to analyze the association strength between baseline SUA level and the all-cause death risk,and to explore the difference between urban and rural areas.The used software was SPSS 26.0 and R 4.0.3.Results As of March 31,2021,the median of following-up time was 6.75 years(P25-P75:6.63-11.10 years),the mortality was 14.87％(665/4 471),and the death density was 183.23/104 person-years.Multivariate Cox proportional hazard regression model showed that when SUA level in total population increased 10 μmol/L,the all-cause death risk increased 1.30％(HR=1.013,95％CI:1.003-1.022);the all-cause death risk in the hyperuricemia group was 0.280 times higher than that in the non-hyperuricemia group(HR=1.280,95％CI:1.013-1.618).In rural elderly population,when SUA level increased 10 μmol/L,HR value was 1.021(95％CI:1.006-1.036),and the all-cause death risk in hyperuricemia group was 0.752 times higher than that in non-hyperuricemia group(HR=1.752,95％CI:1.227-2.503).In the male elderly,when SUA level increased 10μmol/L,the all-cause death risk increased 1.40％(HR=1.014,95％CI:1.001-1.027),and the all-cause death risk in the hyperuricemia group was 0.291 times higher than that in the non-hyperuricemia group(HR=1.291,95％CI:0.974-1.711);in rural male elderly,when SUA level increased 10 μmol/L,the all-cause death risk increased 2.20％(HR=1.022,95％CI:1.002-1.043),the all-cause deathrisk in hyperuricemia group was 0.804 times higher than that in non-hyperuricemia group(HR=1.804,95％CI:1.169-2.783),P＜0.05.Conclusion In urban and rural elderly of Beijing,SUA level is closely related to the increased all cause risk,and hyperuricemia is an independent risk factor for all-cause death,specially in rural elderly and male elderly.
ElderlySerum uric acidHyperuricemiaAll-cause deathCohort study
NETL
NSTL
万方数据
